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ADRA1D receptor antagonist 1 HCl
CAS No. 1191908-14-1
ADRA1D receptor antagonist 1 HCl ( —— )
产品货号. M32771 CAS No. 1191908-14-1
ADRA1D receptor antagonist 1 是一个高效、选择性的，有口服活性的 α1D 肾上腺素受拮抗剂，Ki 值为 1.6 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥2571 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ADRA1D receptor antagonist 1 HCl
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ADRA1D receptor antagonist 1 是一个高效、选择性的，有口服活性的 α1D 肾上腺素受拮抗剂，Ki 值为 1.6 nM。
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产品描述ADRA1D receptor antagonist 1 is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM.
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体外实验ADRA1D receptor antagonist 1 shows low hERG inhibition.ADRA1D receptor antagonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs .
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体内实验ADRA1D receptor antagonist 1 (4.4 μg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO.Animal Model:Rat with bladder outlet obstruction (BOO)Dosage:4.4 μg/kgAdministration: Intravenous injectionResult:Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO.
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同义词——
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通路GPCR/G Protein
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靶点Adrenergic Receptor
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受体Adrenergic Receptor
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研究领域——
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适应症——
化学信息
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CAS Number1191908-14-1
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分子量337.2
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分子式C15H14Cl2N4O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (296.56 mM; 超声助溶 )
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SMILESCl.C[C@H](c1cccc(c1)C#N)n1cc(Cl)cc(C(N)=O)c1=N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sakauchi N, et al. Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ethe?
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